Tunable pH-sensitive 2-carboxybenzyl phosphoramidate cleavable linkers
نویسندگان
چکیده
منابع مشابه
Cleavable linkers for porous silicon-based mass spectrometry.
Desorption/ionization on silicon mass spectrometry (DIOSMS) uses porous silicon (pSi) to generate gas-phase ions of small (< 3000 Da) molecules without a matrix by using standard MALDI (matrix-assisted laser desorption/ionization) instrumentation. The unique laser desorption/ionization surface properties of DIOSMS allow for the simultaneous detection of a broad range of small molecules as their...
متن کاملCyclic acetals as cleavable linkers for affinity capture.
Labeling proteins with biotin is a widely used method to identify target proteins due to biotin's strong binding affinity for streptavidin. Combined with alkyne-azide cycloaddition, which enables the coupling of probes to targeted proteins, biotin tags linked to an alkyne or azide have become a powerful tool for purification and analysis of proteins in proteomics. However, biotin requires harsh...
متن کاملSafety-Catch and Multiply Cleavable Linkers in Solid- Phase Synthesis
This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and “small” organic molecules, as well as their limitations for particular chemistries and reaction conditions. © 1999 John Wiley & Sons, Inc. Biopoly 47: 353–363, 1998
متن کاملTunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials.
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate of degradation and the release rate of entrapped cargo and yield a material that is intrinsically nontoxic. In this work, we designed nontoxic acid-sensitive biomaterials based on silyl ether chemistry. A host of silyl e...
متن کاملEvaluation of ¹¹¹In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers
BACKGROUND Cleavable linkers, which are specifically cleaved by defined conditions or enzymes, are powerful tools that can be used for various purposes. Amongst other things, they have been successfully used to deliver toxic payloads as prodrugs into target tissues. In this work novel linker sequences targeting meprin β, a metalloprotease expressed in the kidney brush-border membrane, were desi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2020
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2020.151650